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K9 Advantix by Bayer Healthcare contains the ingredients Imidacloprid and Permethrin. This makes Advantix an ideal and safe monthly external spot-on tick, flea and mosquito treatment for your dog or your puppy (aged 7 weeks or older). Because K-9 Advantix can kill fleas, ticks and mosquitos as well as repel them, it offers your pet greater protection when compared to other brands recommended by veterinary practitioners. Advantix For Dogs prevents flea bites within 5 minutes and destroys all fleas (98 - 100%) in 12 hours.